Emory University
Radiation Safety Office
Laboratory Worker Training Manual
BIOLOGICAL EFFECTS OF RADIATION
With
a perspective of typical levels of radiation exposure from different sources,
the next question is what effects do exposure to radiation create and what
do these effects depend on?
Radiation biology is the study of the effects of
exposure to radiation and their relationship to dose. These effects
progress according to the following chain of events:
Radiation
interacts producing ions, free radicals and chemically active species.
Chemical reactions
change a biologically significant structure or interfere with a biological
process.
An abnormal
cell or species is created that may lead to further such material.
(most of the ions and chemical
species either do nothing or are so destructive that the result is
simply discarded trash and is subsequently repaired by systems in the body)
Eventually
the biological system is sufficiently upset that observable clinical symptoms
can be observed and treated.
The
expression of the effects depends for a large part on the amount of time
spent around the radiation source. An acute exposure refers to an
exposure time that is very short or a one time exposure to a specific
amount of radiation. A chronic exposure refers to an exposure over
a longer period of time such a one extended over hours or days or a perpetual
exposure. The effects can be divided into three categories:
Somatic
effects are observed in the exposed person.
Prompt
somatic effects are observable soon after a large acute dose
(see previous table). Delayed somatic effects such as
cancer may occur as late as 30 years following exposure.
Genetic
effects are abnormalities that occur in future children of
exposed individuals and in subsequent generations.
Teratogenic
effects may be observed in children who were exposed during
the fetal and embryonic stages
of development.
To better put into perspective the types of risk
one is taking by being occupationally exposed to radiation, a risk comparison
is shown in the table at the right which estimates days of life expectancy
lost on average from various risks. The table shows an estimate
of 15 days of life expectancy lost from receiving 300 mrem/yr of occupational
radiation dose. This data is taken from the NRC Draft guide DG-8012
and were adapted from B.L. Cohen and I.S. Lee, "Catalogue of Risks Extended
and Updates", Health Physics, Vol. 61, Sept 1991. Laboratory workers
at Emory do not receive exposures near 300 mrem/yr.
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